Metabolic Diseases

Atherosclerosis : Artery blockage leading to heart disease

Atherosclerosis is a chronic inflammatory disease characterized by the deposit of plaque mainly composed of lipids on the wall of the arteries. Atherosclerosis is the primary cause of ischemic heart disease, peripheral vascular disease and strokes. In 2022, approximately 6% of adults worldwide were affected by atherosclerosis of the lower limb arteries and this prevalence is continuously rising. Since cholesterol metabolism represents a crucial element in the pathogenesis of atherosclerosis, lipid-lowering drugs have long been used as the main clinical treatment for AS, such as statins, cholesterol absorption inhibitors and PCSK-9 inhibitors. Recent advances have shown that macrophage M1/M2 modulators that reduce macrophage infiltration and polarization in the arterial wall could provide a new therapeutic option for the prevention and treatment of atherosclerosis.

of people affected 
worldwide

> 0 MM

Global Health costs
for ATHEROSCLEROSIS

> 0 bn

pharmacological  
treatments to date

Models

We offer established and validated rodent models of atherosclerosis for chronic efficacy and MoA studies. Our preclinical studies have covered the vast majority of all commercially available rodent models.

Genetic models

ApoE mice

Induced models

ApoE mice on High Fat Diet

Methods

We master gold-standard methods to provide you with high-added value data about your health products’ efficacy and mechanisms of action on key hallmarks of atherosclerosis such as food intake, body weight, total cholesterol, HDL and LDL levels, inflammatory biomarkers, aorta plaque deposit quantification.