Metabolic Diseases

Obesity : Excess body fat impacting health

Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. In 2016, more than 1.9 billion adults aged 18 years and older were overweight. Of these over 650 million adults were obese. In 2018, an estimated 40 million children under the age of 5 years were overweight or obese. To date, despite a very high medical need, only six anti-obesity agents are approved by the FDA, i.e., Orlistat, phentermine/topiramate, naltrexone/bupropion, liraglutide, semaglutide and setmelanotide.

of people affected 
worldwide

> 0 MM

Global Health costs
for OBESITY

> 0 bn

pharmacological  
treatments to date

Models

We offer a variety of established and validated rodent models of overweight and obesity for chronic efficacy and MoA studies. We highly recommend utilizing nutritional models that better mimic and exhibit key hallmarks of human obesity. Our preclinical obesity studies have covered the vast majority of all commercially available rodent models.

Nutritional models

Overweight mouse models
DIO mouse models
DIO rat models

Genetic models

ob/ob mice
db/db mice
ZDF rats

Methods

We master gold-standard methods to provide you with high-added value data about your health products efficacy and mechanisms of action on key hallmarks of obesity such as food intake, body weight, body composition, energy expenditure or circulating plasma biomarkers. In addition, we offer complementary techniques that allow performing fecal microbiome analysis, as well as histological, proteomic, and genomic analyses on key tissues and organs.