Muscle-wasting Conditions

Cachexia : Severe muscle wasting and weight loss condition

Cachexia is a multifactorial syndrome and represents the main cause of mortality in late stages of chronic conditions such as COPD, AIDS, congestive heart failure and cancer. In 2011, an international consensus statement defined cancer cachexia as: ”a multifactorial syndrome characterized by ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment.” The main clinical presentations of cachexia in cancer patients are involuntary weight loss, anorexia, systemic inflammation, insulin resistance, and increased resting energy expenditure.

of people affected 
worldwide

> 0 MM

Global Health costs
for cachexia

> 0 bn

pharmacological  
treatment to date

Models

We have developed and characterized two cancer cachexia mice models induced by a subcutaneous inoculation of Lewis Lung carcinoma or C26 cells.

LLC-induced cancer cachexia in mice
C26-induced cancer cachexia in mice

Methods

We master gold-standard methods to provide you with high-added value data about your health products’ efficacy and mechanisms of action on key hallmarks of cancer-cachexia such as food intake, body weight, body composition, tumor growth, muscular performance and circulating plasma biomarkers. In addition, we offer complementary techniques that allow performing histological and genomic analyses on key tissues and organs.